CHOLESTEROL CONTROL WITH PHYTOTHERAPHY
Cholesterol, a separate and specialized type of lipids, is an essential substance for life.
Cholesterol is the most common steroid in humans and has specific functions in the body. For example, cholesterol is a component of all cell membranes and is the precursor to bile salts, steroid hormones, and vitamin D.
LDL-C is a cause of atherosclerotic cardiovascular disease. A decrease of 1 mmol / L in LDL-C is associated with a decrease of 10% in all-cause mortality, 20% in mortality due to coronary heart disease, 21% and 23% in fatal and non-fatal events, respectively.
However, the risk of residual coronary heart disease continues after LDL-C is reduced to the recommended level. Then we also need the help of our friendly cholesterol: HDL-C
What are the protective effects of HDL-C? Reverse cholesterol transport, decrease in oxidative change of LDL-C, etc.
Cholesterol is found in different amounts in different tissues in the organism. It is most commonly found in nerve tissue, adrenal glands, and egg yolk. Then I hear you say that we shouldn’t consume egg yolk. The answer is we should!
A 20% reduction in egg consumption causes an insufficient intake of lecithin and choline. We need lecithin to control serum cholesterol levels and the most natural source of Lecithin is egg yolk, corn oil, and soybeans.
Diet, regular exercise, and medication are among the most recent treatments for lowering blood cholesterol levels. It is possible to effectively lower high cholesterol levels with various pharmacological agents used in the treatment, but these drugs are not only expensive but also have some side effects.
The most modern and innovative, preventive, and curative treatment method in the world is the evidence-based use of nutraceuticals. One of them is the use of plant sterol/stanol.
A minimum of 1g of plant sterol/stanol per day is required to significantly reduce LDL-C levels. But for a person to take 1g of sterol/stanol per day, he needs to consume about 100g of oil a day? For this reason, 97% of dieticians and 72% of cardiologists in the USA recommend using food supplements to their general patients.
Berberine: Herbal specimens have important applications in Chinese medicine and clinical safety records.
In compounds tested among different plants, Berberine, an alkaloid originally isolated from Huanglian (Coptis Chinensis), showed the highest activity in enhancing LDLR (liver low-density lipoprotein receptor) expression.
In a 2004 study of 91 hypercholesterolemic patients, Berberine reduced serum cholesterol levels by 29%.
Resveratrol: Resveratrol is produced by several plants and is abundant in red grapes – as a component of red wine. Resveratrol was first isolated from the folkloric roots of Ko-jo-kon (Polyganum cuspidatum) that have been used in Japanese traditional medicine for many years.
Resveratrol has been found to exhibit antioxidant, anti-inflammatory, antifibrotic, cardioprotective properties, and powerful antiatherosclerotic effects.
In recent years, the positive effects of resveratrol have been revealed in the treatment of obesity, diabetes, aging, and cancer. It is said that resveratrol, which has all these properties, can be the elixir of youth. 😊
! A study in hyperlipidemic mice showed that the combination of Berberine and Resveratrol reduced serum total cholesterol by 27%.
Silymarin: Derived from the Silybum marianum plant, Silymarin is a traditional herbal medicine widely used in alternative medicine.
A systematic review conducted in 2019 revealed that Silymarin supplementation in combination with other treatments has a positive effect on blood lipids.
Alfalfa (Medicago sativa): Alfalfa consumption in the diet has been found to reduce serum or plasma cholesterol in various animal species.
Many attributed this effect to the presence of saponins in alfalfa. Saponins have been shown to reduce serum and/or liver cholesterol accumulation.
Allium sativum: As a result of clinical studies conducted with the use of garlic, especially LDL cholesterol, total cholesterol, and triglyceride levels decrease and HDL / LDL ratio increases by 12%.
Fruit seed oils: The study conducted in 2019 on high-fat diets; It has shown that plasma cholesterol levels can be reduced by supplementation of tomato, pomegranate, and grape seed oils.
Azadirachta indica: Azadirachta indica has been used in traditional medicine for a long time.
It has been suggested that Myricetin and Quercetin in soluble A. indica extract may play a role in the inhibition of cholesterol absorption.
Tribulus terrestris: Helps treat moderate atherosclerosis and hypertension by helping to lower blood cholesterol and triglyceride levels. The use of 400-800 mg of an extract rich in steroidal saponins per day shows positive results in the improvement of vascular health.
Plantago psyllium: P. psyllium species carry a high amount of mucilage and are used commercially to obtain mucilage. Therefore, they provide regularity in bowel movements.
Psyllium fiber effectively enhances alternative lipid markers and potentially delays the risk of cardiovascular disease associated with atherosclerosis in those with or without hypercholesterolemia.
In addition, psyllium fiber taken before meals contributes to increasing the effectiveness of statins. (lipid-lowering drugs)
Linum usitatissimum: Linseed oil carries omega fatty acid components. Perfect! But the use of flax seeds is more effective than using only the oil for this issue. Because flax seeds are food with fiber. Besides oil; they contain water-soluble and insoluble polysaccharides. Their water-soluble structure prevents the absorption of cholesterol in the body and reduces cholesterol. It has also been suggested that high fiber content is responsible for its LDL-cholesterol lowering effect.
It is recommended to use 1-2 tablespoons of freshly ground flax seeds daily.
Red Yeast Rice and Monacolin K: Red Yeast Rice is a traditional Chinese fermentation product. It is also known as hongqu or red Koji. Pigments with an oligocetid structure are produced by yeasts and these mainly create aesthetically pleasing images in red, orange or yellow color.
In modern medicine, instead of synthetic statins, lovastatin analog, Monacolin K, which is a natural statin, has started to be preferred much more frequently especially in those with statin intolerance.
Red Yeast Rice has anti-inflammatory, normotensive, cholesterol-lowering, cardioprotective, antidiabetic, anticancer, and osteogenic effects.
Citrus bergamia: Citrus bergamia has a very high flavonoid content and unique composition.
It shows markedly hypocholesterolemic and antioxidant/radical scavenging activity.
Glucomannan: It is obtained from the roots of the konjac plant (Amorphophallus konjac K. Koch).
Glucomannan cannot be digested in the human small intestine and thus ıt reduces serum total cholesterol (11%) and LDL-cholesterol concentrations (7%). This effect is seen not only in hypercholesterolemic patients but also in normocholesterolemic individuals.